Silica core-shell particles for the dual delivery of gentamicin and rifamycin antibiotics.

ALVAREZ G.; AIME G.; LUCANGIOLI S.; FLOR S.; CORADIN T.; MEBERT A.; SHI Y.; DESIMONE M.

JOURNAL OF MATERIALS CHEMISTRY

ROYAL SOC CHEMISTRY

Lugar: CAMBRIDGE; Año: 2016 vol. 4 p. 3135 - 3144

0959-9428

Increasing bacterial resistance calls for the simultaneous delivery of multiple antibiotics. One strategy is todesign a unique pharmaceutical carrier that is able to incorporate several drugs with different physicochemicalproperties. This is highly challenging as it may require the development of compartmentalizationapproaches. Here we have prepared core?shell silica particles allowing for the dual delivery of gentamicinand rifamycin. The effect of silica particle surface functionalization on antibiotic sorption was first studied,enlightening the role of electrostatic and hydrophobic interactions. This in turn dictates the chemicalconditions for shell deposition and further sorption of these antibiotics. In particular, the silica shelldeposition was favored by the positively charged layer of gentamicin coating on the core particlesurface. Shell modification by thiol groups finally allowed for rifamycin sorption. The antibacterial activityof the core?shell particles against Staphylococcus aureus and Pseudomonas aeruginosa demonstratedthe dual release and action of the two antibiotics.