IQUIMEFA   05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
Antiproliferative activity of Larrea divaricata Cav. on a lymphoma cell line: participation of hydrogen peroxide in its action
Autor/es:
ROBERTO DAVICINO; MARIA GABRIELA MANUELE; SEBASTIAN TURNER; GRACIELA FERRARO; CLAUDIA ANESINI
Revista:
CANCER INVESTIGATION
Editorial:
Taylor and Francis
Referencias:
Lugar: USA; Año: 2008
ISSN:
0735-7907
Resumen:
Larrea divaricata is a plant used in Argentina. The aim was to analyze the participation
of H2O2 in the antiproliferative effect of L divaricata on BW 5147 cells. Different
studies were performed: proliferation, viability, nitrite production, apoptosis, oxygen
reducing activity, NF-kB translocation, H2O2 production, H2O2 scavenging activity and
effect on exogenous superoxide dismutase. The extract decreased proliferation and
induced apoptosis through P-38 and ERK pathways. The extract activated Mn2+SOD
increasing H2O2 which was implicated in the antiproliferative mechanism by increasing
of nitric oxide. New drugs which can increase H2O2 could be a therapeutic strategy for
the treatment of cancer.is a plant used in Argentina. The aim was to analyze the participation
of H2O2 in the antiproliferative effect of L divaricata on BW 5147 cells. Different
studies were performed: proliferation, viability, nitrite production, apoptosis, oxygen
reducing activity, NF-kB translocation, H2O2 production, H2O2 scavenging activity and
effect on exogenous superoxide dismutase. The extract decreased proliferation and
induced apoptosis through P-38 and ERK pathways. The extract activated Mn2+SOD
increasing H2O2 which was implicated in the antiproliferative mechanism by increasing
of nitric oxide. New drugs which can increase H2O2 could be a therapeutic strategy for
the treatment of cancer.2O2 in the antiproliferative effect of L divaricata on BW 5147 cells. Different
studies were performed: proliferation, viability, nitrite production, apoptosis, oxygen
reducing activity, NF-kB translocation, H2O2 production, H2O2 scavenging activity and
effect on exogenous superoxide dismutase. The extract decreased proliferation and
induced apoptosis through P-38 and ERK pathways. The extract activated Mn2+SOD
increasing H2O2 which was implicated in the antiproliferative mechanism by increasing
of nitric oxide. New drugs which can increase H2O2 could be a therapeutic strategy for
the treatment of cancer.2O2 production, H2O2 scavenging activity and
effect on exogenous superoxide dismutase. The extract decreased proliferation and
induced apoptosis through P-38 and ERK pathways. The extract activated Mn2+SOD
increasing H2O2 which was implicated in the antiproliferative mechanism by increasing
of nitric oxide. New drugs which can increase H2O2 could be a therapeutic strategy for
the treatment of cancer.2+SOD
increasing H2O2 which was implicated in the antiproliferative mechanism by increasing
of nitric oxide. New drugs which can increase H2O2 could be a therapeutic strategy for
the treatment of cancer.2O2 which was implicated in the antiproliferative mechanism by increasing
of nitric oxide. New drugs which can increase H2O2 could be a therapeutic strategy for
the treatment of cancer.2O2 could be a therapeutic strategy for
the treatment of cancer.
Keywords: Lymphocytes, proliferation, hydrogen peroxideLymphocytes, proliferation, hydrogen peroxide