IQUIMEFA 05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
Divergent synthetic routes to biologically relevant types of compounds: chiral polyfunctional-g-lactams and amino acids
Autor/es:
AGUILERA, JORDI; MOGLIONI, ALBERTINA; MOR, ALEX; OSPINA, JIMENA; ILLA, ONA; ORTUNO, ROSA M.
Revista:
TETRAHEDRON
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2014 vol. 70 p. 6546 - 6553
ISSN:
0040-4020
Resumen:
Divergent and versatile synthetic routes leading to the title compds. are described. They start from a common chiral precursor derived from (-)-(S)-verbenone and afford polyfunctional γ-lactams and γ- and ε-amino acids. The cyclobutane moiety in these mols. acts as a chiral and polyfunctional platform providing stereogenic centers with unambiguous abs. configuration that control the chirality of the newly produced asym. carbons. Furthermore, it affords functional groups and carbon chains suitable not only to create the basic skeleton of the desired products but addnl. functional groups. These features confer on these derivs. a great versatility for further uses in the development of new drugs and as synthetic building blocks.
