HYBANTHUS PARVIFLORUS AND H.BIGIBBOSUS (VIOLACEAE): ACUTE AND SUBCHRONIC ORAL TOXICITY ASSESSMENT OF HYDROALCOHOLIC EXTRACTS IN RODENTS.

CUFRE, IM; TARCAYA, V.; BROUSSALIS, A. M.; MIÑO, J. H.

REVISTA LATINOAMERICANA DE QUIMICA

MIXIM S.A. México

Año: 2013 p. 1 - 10

0370-5943

Abstract Plants have been used throughout the ages for combat microorganisms and insects. Currently, several studies have confirmed many of the biological activities attributed to them. However, it is also important to evaluate the toxic or deleterious effects that their use could cause in the short, medium or long term in the human health and the environment and take into account the possible routes of exposure for humans. The aim of the present study was to evaluate the acute toxicity in mice, the sub-acute toxicity in rats, and the dermal and ocular toxicity in rabbits of the 50% hydroalcoholic extracts from aerial parts of Hybanthus parviflorus and Hybanthus bigibbosus, two species with insecticidal activity. The 50% EtOH extracts of both species did not present acute nor subchronic oral toxicity, and did not produced dermal irritation or ocular toxicity. These promising results would be a useful tool in the development of a selective natural insecticide, to be used in a sustainable handling of plagues, safe for the human health and the environment.