Antiproliferative activity of Larrea divaricata Cav. on a lymphoma cell line: participation of hydrogen peroxide in its action

ROBERTO DAVICINO; MARIA GABRIELA MANUELE; SEBASTIAN TUIRNER; GRACIELA FERRARO; CLAUDIA ANESINI

CANCER INVESTIGATION

Taylor & Francis Group

Lugar: Londres; Año: 2010 vol. 28 p. 13 - 22

0735-7907

Larrea divaricata is a plant used in Argentina. The aim was to analyze the participation of H2O2 in the antiproliferative effect of L divaricata on BW 5147 cells. Different studies were performed: proliferation, viability, nitrite production, apoptosis, oxygen reducing activity, NF-kB translocation, H2O2 production, H2O2 scavenging activity and effect on exogenous superoxide dismutase. The extract decreased proliferation and induced apoptosis through P-38 and ERK pathways. The extract activated Mn2+SOD increasing H2O2 which was implicated in the antiproliferative mechanism by increasing of nitric oxide. New drugs which can increase H2O2 could be a therapeutic strategy for the treatment of cancer.is a plant used in Argentina. The aim was to analyze the participation of H2O2 in the antiproliferative effect of L divaricata on BW 5147 cells. Different studies were performed: proliferation, viability, nitrite production, apoptosis, oxygen reducing activity, NF-kB translocation, H2O2 production, H2O2 scavenging activity and effect on exogenous superoxide dismutase. The extract decreased proliferation and induced apoptosis through P-38 and ERK pathways. The extract activated Mn2+SOD increasing H2O2 which was implicated in the antiproliferative mechanism by increasing of nitric oxide. New drugs which can increase H2O2 could be a therapeutic strategy for the treatment of cancer.2O2 in the antiproliferative effect of L divaricata on BW 5147 cells. Different studies were performed: proliferation, viability, nitrite production, apoptosis, oxygen reducing activity, NF-kB translocation, H2O2 production, H2O2 scavenging activity and effect on exogenous superoxide dismutase. The extract decreased proliferation and induced apoptosis through P-38 and ERK pathways. The extract activated Mn2+SOD increasing H2O2 which was implicated in the antiproliferative mechanism by increasing of nitric oxide. New drugs which can increase H2O2 could be a therapeutic strategy for the treatment of cancer.2O2 production, H2O2 scavenging activity and effect on exogenous superoxide dismutase. The extract decreased proliferation and induced apoptosis through P-38 and ERK pathways. The extract activated Mn2+SOD increasing H2O2 which was implicated in the antiproliferative mechanism by increasing of nitric oxide. New drugs which can increase H2O2 could be a therapeutic strategy for the treatment of cancer.2+SOD increasing H2O2 which was implicated in the antiproliferative mechanism by increasing of nitric oxide. New drugs which can increase H2O2 could be a therapeutic strategy for the treatment of cancer.2O2 which was implicated in the antiproliferative mechanism by increasing of nitric oxide. New drugs which can increase H2O2 could be a therapeutic strategy for the treatment of cancer.2O2 could be a therapeutic strategy for the treatment of cancer.