In vitro immunomodulatory effects of fractions obtained from aqueous extracts of Larrea divaricata Cav (Jarilla) on mouse peritoneal macrophages

RENZO MARTINO; ROBERTO DAVICINO; MARIA A MATTAR; YOLANDA CASALI; SILVIA CORREA; CLAUDIA ANESINI; BLAS MICALIZZI

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Informa Healthcare

Lugar: LONDON; Año: 2010 vol. 32 p. 125 - 132

0892-3973

Background and aim: Larrea divaricata Cav. (Zygophyllaceae) is a plant widely used in Argentina.(Zygophyllaceae) is a plant widely used in Argentina. Material and methods: We isolated different fractions of L. divaricata aqueous extract containing minor amounts of NDGA, and we analyzed these fractions on mouse macrophages. amounts of NDGA, and we analyzed these fractions on mouse macrophages. amounts of NDGA, and we analyzed these fractions on mouse macrophages. We isolated different fractions of L. divaricata aqueous extract containing minor amounts of NDGA, and we analyzed these fractions on mouse macrophages. Results: We showed that a fraction without NDGA was capableof activating macrophages, principally through the production of mitochondrial anion superoxide and H2O2. This could be important in the defense of infections. Moreover, this fraction decreased NO level suggesting an anti-inflammatory action. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. defense of infections. Moreover, this fraction decreased NO level suggesting an anti-inflammatory action. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. defense of infections. Moreover, this fraction decreased NO level suggesting an anti-inflammatory action. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. through the production of mitochondrial anion superoxide and H2O2. This could be important in the defense of infections. Moreover, this fraction decreased NO level suggesting an anti-inflammatory action. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. defense of infections. Moreover, this fraction decreased NO level suggesting an anti-inflammatory action. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata. action exerted by the aqueous extract from L. divaricata.