UMYMFOR 05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Semi-synthetic analogues of dihydrocucurbitacin B
Autor/es:
LANG K. L.; ZIMMERMANN L. A.; MACHADO V. R.; DURÁN F. J.; CARO M. S. B.; SCHENKEL, E.P
Lugar:
Ouro Preto
Reunión:
Simposio; 5th Brazilian Symposium on Medicinal Chemistry; 2010
Institución organizadora:
Brazilian Chemical Society (SBQ). Division of Medicinal Chemistry.
Resumen:
Cucurbitacins are highly oxygenated tetracyclic triterpenes found predominantly in plants of the family Cucurbitaceae. Previous studies showed that these compounds are responsible for the broad spectrum of biological activities of these plants, highlighting anti-inflammatory and antitumoral activities, but with high toxicity. There isnt studies of structure-activity relationship which have established the regions of the molecule responsible for the biological action and toxicity. In this sense, we synthesized dihydrocucurbitacin B derivatives, aiming to establish the parts of the structure responsible for different actions.
