UMYMFOR 05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Trypanosoma brucei: Endogenousbiosynthesis of ubiquinone 9 and exogenous uptake of unbiquinone 10
Autor/es:
BONTEMPI, ESTEBAN J.; FUSCO, OCTAVIO; POROPAT, ESTEFANÍA; ENGEL, JUAN C.; RODRIGUEZ, JUAN BAUTISTA
Lugar:
Mar del Plata
Reunión:
Simposio; X Congreso de Protozoología y Enfermedades Parasitarias; 2014
Institución organizadora:
Sociedad Argentina de Protozoología
Resumen:
Our aim is to validate the solanesyl diphosphate synthase (SPPS) as a new target for trypanosomatids. The Trypanosoma brucei mithocondrial enzyme (Lai 2012) is essential as demonstrated by RNAi experiments (Lai 2014): Identical metabolic effects were obtained bu inhibiting the bloodstream forms with 1-[(n-oct-1-ylamino)ethyl]-1,1-bisphosphonic acid, a bisphosphonate originally developed against the T. cruzi homologue enzyme (Ferella 2006, Szajnman 2008).
