Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa

ROJO DE ALMEIDA, M.T.; RÍOS-LUCI, C.; PADRÓN, J. M.; PALERMO, J

PHYTOCHEMISTRY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2010 vol. 71 p. 1741 - 1748

0031-9422

Investigation of the organic extracts of the roots of Maytenus vitis-idaea and Maytenus spinosa, collected in the province of Salta, Argentina, led to the isolation of eighteen compounds belonging to several classes. From M. vitis-idaea, eight methylenequinone celastroids (1-8) were isolated, four of which (4-7) are new compounds, while from M. spinosa, two known celastroids, a known celastroid dimer (9), three pentacyclic triterpenoids (10-12) and six b-dihydroagarofuran sesquiterpenoid alkaloids (13-18) could be identified.  The pentacyclic terpenoids 11-12 and alkaloids 17-18 have not been previously reported. Compounds 4-7 were active against six solid tumor cell lines at micromolar concentrations.