UMYMFOR   05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Highly stereoselective synthesis of steroidal 2,5-diketopiperazines based on isocyanide chemistry
Autor/es:
BRUTTOMESSO ANDREA C.; EIRAS JAVIER; RAMÍREZ JAVIER A.; GALAGOVSKY LYDIA R
Revista:
TETRAHEDRON LETTERS
Editorial:
Elsevier
Referencias:
Año: 2009 vol. 50 p. 4022 - 4024
ISSN:
0040-4039
Resumen:
In this Letter we report that the Ugi reaction/cyclization sequence on a steroidal 17-carboxaldehyde leadsto novel steroidal 2,5-diketopiperazines with a noteworthy stereoselectivity. A wide variety in the substitutionpattern in the heterocyclic moiety was easily achieved by changing the components in theUgi reaction.