Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated

FLAVIA M. MICHELINI; JAVIER A. RAMIREZ; ALEJANDRO BERRA; LYDIA R. GALAGOVSKY; LAURA E. ALCHÉ

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Elsevier

Año: 2008 vol. 111 p. 111 - 116

0960-0760

Stromal keratitis resulting from ocular infection with Herpes simplex virus type 1 (HSV-1) is a common cause of blindness. This report investigates the antiviral and anti-inflammatoryproperties of two new synthetic stigmastane analogs in the experimental model of HSV-1-induced ocular disease in mice.(22S,23S)-22,23-dihydroxystigmast-4-en-3-one (1) and (22S,23S)-22,23-dihydroxystigmasta-1,4-dien-3-one (2) exhibited anti-HSV-1 activity in vitro and ameliorated thesigns of murine herpetic stromal keratitis (HSK), although none of the compounds showedantiviral activity in vivo. We discuss that the improvement of HSK could be due to animmunomodulatory effect of both compounds.