UMYMFOR 05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
An efficient enzymatic preparation of 20-pregnane succinates: chemoenzymatic synthesis of 20beta-hemisuccyniloxy-5alfaH-pregnane-3-one
Autor/es:
MONSALVE, LEANDRO N.; MACHADO RADA, MAYRA Y.; GHINI, ALBERTO A.; BALDESSARI, A.
Revista:
TETRAHEDRON
Editorial:
Elsevier B. V.
Referencias:
Año: 2008 vol. 64 p. 1721 - 1730
ISSN:
0040-4020
Resumen:
The lipase-catalyzed transesterification of the 20 hydroxyl group in a series of pregnanes allowed to obtain novel 20 ethyl succinates which are not possible to prepare following the traditional synthetic methods. The reaction is highly stereoselective and the ethyl succinates are obtained in variable yield, depending of the substitution in the ring A. The enzymatic approach let to perform the chemoenzymatic synthesis of 20b-hemisuccinyloxy-5aH-pregnan-3-one, precursor of steroid-protein conjugates.
