UMYMFOR 05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Synthesis and antifungal activity of bile acid-derived oxazoles
Autor/es:
BUTASSI, ESTEFANÍA; SÁNCHEZ, MARIANELA; SVETAZ, LAURA; PALERMO, JORGE; FERNÁNDEZ, LUCÍA; ZACCHINO, SUSANA
Revista:
STEROIDS
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Lugar: Amsterdam; Año: 2016 vol. 108 p. 68 - 76
ISSN:
0039-128X
Resumen:
Peracetylated bile acids (1a?g) were used as starting materials for the preparation of fourteen newderivatives bearing an oxazole moiety in their side chain (6a?g, 8a?g). The key step for the synthetic pathwas a Dakin?West reaction followed by a Robinson?Gabriel cyclodehydration. A simpler model oxazole(12) was also synthesized. The antifungal activity of the new compounds (6a?g) as well as their startingbile acids (1a?g) was tested against Candida albicans. Compounds 6e and 6g showed the highest percentagesof inhibition (63.84% and 61.40% at 250lg/mL respectively). Deacetylation of compounds 6a?g, led to compounds 8a?g which showed lower activities than the acetylated derivatives.
