Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by material diets enriched in olive oil

EVANGELINA CAPOBIANCO; MAGALÍ PELSSON; VALERIA CAREAGA; DAIANA FORNES; IVANA CANOSA; ROMINA HIGA; MARTA MAIER; ALICIA JAWERBAUM

Molecular Nutrtion & Food Research

Wiley

Año: 2015 vol. 59 p. 1997 - 2007

Scope: Maternal diabetes can program metabolic and cardiovascular diseases in the offspring.The aim of this work was to address whether an olive oil supplemented diet during pregnancycan prevent lipid metabolic alterations in the heart of the offspring of mild diabetic rats.Methods and results: Control and diabetic Wistar rats were fed during pregnancy with either astandard diet or a 6%olive oil supplemented diet. The heart of adult offspring from diabetic ratsshowed increases in lipid concentrations (triglycerides in males and phospholipids, cholesterol,and free fatty acids in females), which were prevented with the maternal diets enriched in oliveoil. Maternal olive oil supplementation increased the content of unsaturated fatty acids in thehearts of both female and male offspring from diabetic rats (possibly due to a reduction inlipoperoxidation), increased the expression of 6 desaturase in the heart of male offspringfrom diabetic rats, and increased the expression of peroxisome proliferator activated receptor in the hearts of both female and male offspring from diabetic rats.Conclusion: Relevant alterations in cardiac lipid metabolism were evident in the adult offspringof a mild diabetic rat model, and regulated by maternal diets enriched in olive oil.