UMYMFOR 05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Synthesis and biological activity of brassinosteroids fluorinated at C-2.
Autor/es:
SOFÍA L. ACEBEDO; J. A. RAMÍREZ; L. R. GALAGOVSKY
Revista:
STEROIDS
Editorial:
Elsevier
Referencias:
Año: 2009 vol. 74 p. 435 - 440
ISSN:
0039-128X
Resumen:
In this paper we report the synthesis of four fluorinated analogues of brassinosteroids in which fluorine was introduced stereoselectively at C-2. The bioactivity of these new compounds was evaluated using the rice lamina inclination test. The results show that two of these analogues elicit high bioactivity, suggesting the involvement of hydrogen bond interactions between the active brassinosteroids and their cellular receptor.
