UMYMFOR   05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Chemical ecology and bioactivity of triterpene glycosides from the sea cucumber Psolus patagonicus (Dendrochirotida, Psolidae)
Autor/es:
MUNIAIN, CLAUDIA; CENTURIÓN, ROMINA; CAREAGA, VALERIA; MAIER, MARTA S.
Revista:
JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM
Referencias:
Año: 2007
ISSN:
0025-3154
Resumen:
information on the chemical ecology and bioactivity of chemical compounds present in the sea cucumber Psolus patagonicus is provided through an interdisciplinary approach. The specimens studied were collected from two different and very distant sampling localities: Bridges Islands (Beagle Channel, Ushuaia, 54° 48’ 57’’S, 66° 25’ 00’’W) at depths of 4 to 10 m by scuba diving, and from the scallop beds of Zigochlamys patagonica (39° 27’ 10’’S, 55° 56’ 76’’W), at depths of 110 m and 115 m (43° 47’ 84’’S, 59° 56’ 80’’W) by means of non-selective dredge in the South Atlantic Ocean. The secondary metabolites were isolated from complete adults by a combination of chromatographic methods and purified by HPLC. They were characterised as triterpene glycosides through extensive spectroscopic analyses (NMR, FABMS) and chemical methods. A purified fraction containing Patagonicoside A as the main triterpene showed a high level of mortality against the brine shrimp Artemia salina and revealed different antifungal activity of Patagonicoside A and its desulfated glycoside (ds-Patagonicoside A) against the fungi Cladosporium fulvum, Fusarium oxysporum and Monilia sp, compared with a potent commercial antifungal product.