UMYMFOR   05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Synthesis and antifungal activity of C-21 steroids with an aromatic D ring
Autor/es:
SONEGO, JUAN M.; CIRIGLIANO, ADRIANA M.; CABRERA, GABRIELA M.; BURTON, GERARDO; VELEIRO, ADRIANA S.
Revista:
STEROIDS
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 78 p. 644 - 650
ISSN:
0039-128X
Resumen:
Six analogues of salpichrolides with a simplified side chain (6-11) were synthesized using a new methodology to obtain steroids with an aromatic D-ring. The key step was the elimination of HBr in a vicinal dibromo D-homosteroid by treatment with 1,4-diazabicyclo[2.2.2]octane (DABCO). All new compounds were completely characterized by 2D NMR techniques and tested on two fungal pathogenic species, Fusarium virguliforme and Fusarium solani.