UMYMFOR 05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Synthesis of 6-azaprogesterone and 19-hydroxy-6-azasteroids
Autor/es:
MARTÍNEZ, MARIO D.; EDELSZTEIN, VALERIA C.; DURAN, FERNANDO J.; DI CHENNA, PABLO H.; BURTON, GERARDO
Revista:
STEROIDS
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Año: 2013 vol. 78 p. 34 - 37
ISSN:
0039-128X
Resumen:
19-Hydroxy-6-azapregnanes were obtained from pregnenolone via a 5-oxo-7-azido-secopregnane intermediate. The 6-azapregnane core was built in good yield in a straightforward way from the secosteroid, by means of a Staudinger (aza-Wittig) reaction. Finally the 19-hydroxy-6-azapregnane was transformed into 19-hydroxy-6-azaprogesterone and 6-azaprogesterone. The 6-azapregnanes lacked agonistic/antagonistic activity on the progesterone receptor
