UMYMFOR 05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Chemoselective enzymatic preparation of N-hydroxyalkylacrylamides, monomers for hydrophilic polymer matrices
Autor/es:
EDUARDO M. RUSTOY, ALICIA BALDESSARI
Revista:
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
Editorial:
Elsevier, B. V.
Referencias:
Lugar: Shanon Co. Clare, Irlanda; Año: 2006 vol. 39 p. 50 - 54
ISSN:
1381-1177
Resumen:
A lipase-catalyzed procedure is described for the preparation of N-hydroxyalkylacrylamides useful across a number of electrophoretical applications such as capillary and gel electrophoresis. The N-hydroxyalkylacrylamides were prepared through an aminolysis reaction of alcanolamines on ethyl acrylate. The reacion was catalyzed by Candida antarctica lipase. The addition of radical inhibitors improved chemoselectivity and amides were obtained in high yield and purity at room temperature.
