UMYMFOR 05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Anti-Infective Pregnane Steroid from the Octocoral Carijoa riisei Collected in South Brazil
Autor/es:
ROJO DE ALMEIDA, M.T.; TONINI, M.; GUIMARAES, T.; BIANCO, E.; MORITZ, M.I.; DE OLIVEIRA, S.; CABRERA, G.; PALERMO, J.; REGGINATO, F.; STEINDEL; SCHENKEL, E.
Revista:
ACTA FARM. BONAERENSE
Editorial:
COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
Referencias:
Lugar: Buenos Aires; Año: 2012 vol. 31 p. 1489 - 1495
ISSN:
0326-2383
Resumen:
SUMMARY. In the present work, fractions of the ethanolic crude extract of Carijoa riisei (Octocorallia)
collected at South Brazil (Santa Catarina island) were tested against different bacterial, fungal and protozoal
pathogens. The n-hexane fraction (HF) showed a moderate activity against S. aureus in the disk diffusion
method, and inhibited 43.4 and 35.9 % the growing of T. cruzi epimastigotes and L. braziliensis promastigotes,
respectively. The steroid pregna-1,4,20-trien-3-one was isolated from HF and presented in vitro
antiprotozoal activity against the extracellular forms of the parasites at 50 μM, showing 50.4 % growth inhibition
of L. braziliensis and 42.4 % growth inhibition of T. cruzi.
