Patagonicosides B and C, two antifungal sulfated triterpene glycosides from the sea cucumber Psolus patagonicus

VALERIA P. CAREAGA; CLAUDIA MUNIAIN; MARTA S. MAIER

Chemistry and Biodiversity

WILEY-V C H VERLAG GMBH

Año: 2011 vol. 8 p. 467 - 475

1612-1872

Two new triterpene glycosides, Patagonicoside B (2) and Patagonicoside C (3), together with the known Patagonicoside A (1), have been isolated from the ethanolic extract of the sea cucumber Psolus patagonicus. The structures of the new compounds were established on the basis of extensive NMR spectroscopy (1H and 13C NMR, 1H1H COSY, HMBC, HSQC, TOCSY, and NOESY), HRESIMS, and chemical transformations. Compounds 1-3 and their desulfated analogs showed antifungal activity against the pathogenic fungus Cladosporium cladosporoides. in a concentration dependent manner.