UMYMFOR 05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Biocatalytic synthesis of chiral N-(2-hydroxyalkyl)-acrylamides
Autor/es:
LEANDRO N. MONSALVE; EDUARDO M. RUSTOY; ALICIA BALDESSARI
Revista:
BIOCATALYSIS AND BIOTRANSFORMATION
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Lugar: Londres; Año: 2011 vol. 29 p. 87 - 95
ISSN:
1024-2422
Resumen:
The preparation of a series of novel chiral N-(2-hydroxylalkyl)-acrylamides through a lipase-catalyzed resolution of racemic alkanolamines is described. The absolute stereochemistry and enantiomeric excess of the products were determined by a modified Mosher?s method. This method was validated for this particular case by the synthesis of an enantiomerically pure product. Moreover, the stereoselective behavior of the lipase in this reaction was discussed.
