UMYMFOR 05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Trypanosoma cruzi squalene synthase is a major target for 2-alkylaminoethyl-1,1-bisphosphonates
Autor/es:
RODRIGUES-POVEDA, CARLOS A.; GONZÁLEZ-PACANOWSKA, DOLORES; SZAJNMAN, SERGIO HERNÁN; RODRIGUEZ, JUAN BAUTISTA
Revista:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Editorial:
AMER SOC MICROBIOLOGY
Referencias:
Lugar: Washington; Año: 2012 vol. 56 p. 4483 - 4486
ISSN:
0066-4804
Resumen:
As part of our efforts aimed at searching for new antiparasitic agents, the effect of representative 2-alkylaminoethyl-1,1-bisphosphonic acids on Trypanosoma cruzi squalene synthase (TcSQS) was investigated. These compounds had proven to be potent inhibitors of T. cruzi. This cellular activity had been associated with an inhibition of the enzymatic activity of T. cruzi farnesyl diphosphate synthase. 2-Alkylaminoethyl-1,1-bisphosphonic acids appear to have a dual action, since they also inhibit TcSQS at the nanomolar range.
