UMYMFOR 05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Synthesis of aromatic stigmastanes: application to the synthesis of aromatic analogs of brassinosteroids
Autor/es:
SOFIA L. ACEBEDO; FERNANDO ALONSO; JAVIER A. RAMIREZ; LYDIA R. GALAGOVSKY
Revista:
TETRAHEDRON
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2012 vol. 68 p. 3685 - 3691
ISSN:
0040-4020
Resumen:
In this paper, we report the first synthesis of aromatic analogs of brassinosteroids. In order to accomplish this task, we explored two different synthetic approaches, which involved demethylation of the C-19 of stigmasterol to yield A-ring aromatic 3-hydroxystigmastanes. One of the new aromatic analogs showed a reduced but significant bioactivity when compared to the natural hormones.
