UMYMFOR 05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Structure of the Glucocorticoid Receptor. A Flexible Protein that can Adapt to Different Ligands
Autor/es:
ADRIANA S. VELEIRO, LAUTARO D. ALVAREZ, SILVINA L. EDUARDO, AND GERARDO BURTON
Revista:
CHEMMEDCHEM
Editorial:
WILEY-V C H VERLAG GMBH
Referencias:
Año: 2010 vol. 5 p. 649 - 659
ISSN:
1860-7179
Resumen:
Crystal structures of the glucocorticoid receptor (GR) ligand binding domain in complex with various agonists and antagonists give us an insight on how ligands are recognized by the receptor and how their structure can affect the behavior of the GR. Interestingly, these structural data show how the GR can adapt its binding pocket to accommodate molecules that differ substantially from the natural ligands without loss of function
