Rhodotorula minuta-mediated bioreduction of 1,2-diketones

MONSALVE, LEANDRO N.; CERRUTTI, PATRICIA; GALVAGNO, MIGUEL A.; BALDESSARI, ALICIA

BIOCATALYSIS AND BIOTRANSFORMATION

TAYLOR & FRANCIS LTD

Lugar: Shannon, Irlanda; Año: 2010 vol. 28 p. 137 - 143

1024-2422

<!-- /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:IT;} @page Section1 {size:612.0pt 792.0pt; margin:72.0pt 90.0pt 72.0pt 90.0pt; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> The reduction of cyclic and acyclic 1,2-diketones was investigated by employing whole cells of the yeast Rhodotorula minuta as biocatalyst. While only diols were obtained by by reduction of cyclic diketones, the bioreduction of the acyclic ones allowed us to obtain the corresponding hydroxy ketone or diol depending on reaction time. The formation of the hydroxyketone of (S) configuration was highly regio- and stereoselective while second reduction yielded the corresponding diols predominantly in the anti-configuration as the final products.