Lipase-catalyzed synthesis and characterization of a novel linear polyamidomine oligomer

L. N. MONSALVE; F. K. FATEMA; H. NONAMI; R. ERRA-BALSELLS; A. BALDESSARI

POLYMER

ELSEVIER SCI LTD

Lugar: Oxford, Reino Unido; Año: 2010 vol. 51 p. 2998 - 3005

0032-3861

<!-- /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:Arial; mso-fareast-font-family:"Times New Roman"; color:black; mso-ansi-language:EN-GB; mso-fareast-language:ES;} @page Section1 {size:612.0pt 792.0pt; margin:72.0pt 90.0pt 72.0pt 90.0pt; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> A linear polyamidoamine oligomer was obtained by polymerization of ethyl acrylate and N-methyl-1,3-diaminopropane, catalyzed by the Candida antarctica lipase. Depending on the reaction conditions such as substrates concentration, solvent and enzyme:substrate ratio, the enzyme catalyzes the polymerization reaction or Michael adducts formation. The polymeric material, characterized by FTIR, 1H and 13C NMR and UV-MALDI-TOF-MS, shows low molecular weight and high monodispersity. The activity showed by Candida antarctica lipase in the polymerization reaction is highly selective and allows to obtain a product with potential biomedical applications in mild condition reactions and low environmental impact.