Novel localization of NF-kappa B in mouse forebrain synaptic terminals. Activation dynamics during memory consolidation

MARIA LAGOS; BOCCIA M,; BLAKE M; NICOLETTA CORBI; CLAUDIO PASSANANTI; BARATTI CM; ARTURO ROMANO; FREUDENTHAL, R

Huerta Grande

Congreso; IIRCN; 2010

TAN Y SAN

NF-kappa B activation has recently been shown to be necessary for long-term memory consolidation and reconsolidation, in the inhibitory avoidance learning in the mouse hippocampus. NF-kappa B is activated in the cell nucleus in specific temporal windows in both consolidation and reconsolidation. Previous results showed that the transcription factor is also present in synaptic terminals. This work focuses in the dynamics of its synaptic activation during consolidation, in two different synaptic localizations: soluble in the synaptic content and, in a pool described for the first time in this work, bound to the cell membrane. The function of this novel localization is discussed.