IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Cocaine acute "binge" administration abnormally enhances thalamic GABAergic synaptic transmission in mice.
Autor/es:
BISAGNO VERONICA; RAINERI MARIANA; WIKINSKI SILVIA; UCHITEL OSVALDO; LLINAS RODOLFO; URBANO FRANCISCO
Lugar:
Huerta Grande, Cordoba, Argentina
Reunión:
Congreso; First Joint Meeting of the Argentine Society for Neurosciences (SAN) and the Argentine Workshop in Neurosciences (TAN); 2009
Institución organizadora:
First Joint Meeting of the Argentine Society for Neurosciences (SAN) and the Argentine Workshop in Neurosciences (TAN)
Resumen:
Attentional and sensorial processing deficits in cocaine addicts are relevant to cocaine abuse treatment. Thalamocortical system is involved in sensory processing. However, little is known about possible mechanisms mediating cocaine effects on the thalamocortical circuitry. Here we studied whether cocaine acute "binge" (3x15mg inj. 1 h apart) would enhance GABAergic feed-back transmission from reticular to VB neurons.Also, immunohistochemical experiments were performed on brain slices containing primary somatosensory cortex (S1) and thalamic nuclei using antibodies for Glutamic Acid Decarboxylase (GAD 65/67). These results suggest a possible role of D2/D3 receptors in VB´s GABA-A minis enhancement induced by cocaine. Also, higher number of T-currents-mediated LTS bursts at reticular neuron´s terminals might be  responsible for the enhancement in GABAergic transmission onto the VB nucleus. Absence of changes on GAD immunostaining seems to indicate that GABAergic enhancement is not primarily due to changes in GABAergic terminals.