IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Characterization of the synaptic NF-kB pool.
Autor/es:
FREUDENTHAL RAMIRO; HEPP YANIL; ROMANO ARTURO
Lugar:
Huerta Grande, Córdoba
Reunión:
Congreso; I Reunión Conjunta en Neurociencias (IRCN); 2009
Institución organizadora:
Taller Argentino de Neurociencias y san
Resumen:
The transcription factor NF-kappaB is involved in the gene expression regulation that follows a neuronal plasticity event. In memory models, it activates in a biphasic fashion, translocating to the cellular nucleus immediately after a long term memory inducing training (LTMIT) and 6 hours after. The sub-cellular localization of this transcription factor shows not only a cytoplasmatic perinuclear localization but also a synaptic pool of NF-kappaB, that activates, also after a LTMIT . This work characterizes the NF-kappaB containing synapses as a way of investigating the molecular pathways involved in its activation and its function in the synapse during neuronal plasticity.