IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Control of Rhythmic Motor Behaviors by Cholinergic Inputs
Autor/es:
LIDIA SZCZUPAK.; EZEQUIEL RIOS
Lugar:
BUENOS AIRES
Reunión:
Congreso; 2ND FALAN MEETING; 2016
Institución organizadora:
SOCIEDAD ARGENTINA DE INVESTIGACION EN NEUROCIENCIAS
Resumen:
Rhythmic motor behaviors in animals are controlled by neuronal networks, and motoneurons can be part of this control networks. We analyzed the effect of cholinergic blockers on the central pattern generator (CPG) of crawling in the leech, where motoneurons are cholinergic. The studies were performed in isolated leech ganglia, in which dopamine-induced crawling was monitored by measuring the activity of motoneurons through extracellular recordings of the dorsal posterior nerve. The rhythmic crawling activity was analyzed measuring the cycle period, the duration of the bursts and the firing frequency of the motoneurons in 20-min episodes. The cholinergic input onto the CPG was analyzed by perfusing the ganglia with d-tubocurarine. We found that, compared with control experiments, the cholinergic antagonist affected the three variables, but the effect was not stable along the episode. The results indicate that the crawling CPG is under cholinergic control, and that this cholinergic contribution changes throughout the episode.