IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
THE EFFECT OF STRESS ON ACQUISITION, CONSOLIDATION AND RECONSOLIDATION OF A NEUTRAL DECLARATIVE MEMORY IN HUMANS
Autor/es:
FERNANDEZ RODRIGO; FORCATO CECILIA; PEDREIRA EUGENIA
Reunión:
Encuentro; Primer encuentro de Neurociencias Cognitivas NEUROCOG; 2015
Resumen:
Afteracquisition, the storage process by which a labile short term memory istransformed into a stable long term memory is called consolidation. Thereconsolidation hypothesis posits that the presentation of a specific cue,previously associated with learning, makes the stored memory pass from a stableto an unstable state. In this state, memory is again labile and susceptible todifferent agents, which may either damage or improve the original memory. Suchsusceptibility decreases over time and leads to a re-stabilization phase knownas reconsolidation process.  Aversiveemotional events such as stress affect different memory process in severalways. Little is known about the influence of stress in the acquisition and fateof such memory type. To reach such goal we developed a new adaptation of thesocial stress gold standard, the Trier Social Stress Test , namely Buenos AiresSocial Stress Test (BASST). Here we showed in Experiment 1 and 2, that stressprior the acquisition of a neutral declarative, improves acquisition andenhance consolidation. In Experiment 3, a strong memory initially acquiredunder stress pass through the reconsolidation process and could be interferedby new learning after the presentation of a reminder. Because the age of amemory is proposed as a boundary condition of the reconsolidation, we revealedin Experiment 4 and 5 that seven days after training a proper reminder followedby new learning interfered the reconsolidation of the target memory and thattwo successive presentation of the reminder strengths memory. As a whole, theresults suggest that the fate of a neutral declarative memory acquired after asocial threat result in a strong memory, and under this condition thereconsolidation process per se and the strengthening function is active onolder memories.