IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Reconsolidation or extinction. Bidireccional regulation of NFkB.
Autor/es:
DE LA FUENTE, VERÓNICA; ROMANO, ARTURO
Lugar:
Buzios, Brasil
Reunión:
Congreso; Ier. Congreso IBRO/LARC de de Neurociencias de América Latina, caribe y península Ibérica, Neurolatam; 2008
Institución organizadora:
IBRO-LARC
Resumen:
Evidence supports that the cellular and molecular mechanisms underlying memory consolidation are different from those underlyng reconsolidation and extinction. Differences may rely, not only in the molecules involved, but also in the activation time of these molecules, and even in the brain areas involved. In addition, little is known about the mechanisms of memory extinction. Contrarily wise, increasing evidence supports the participation of the transcription factor NF-kB in memory. It has already been show that in the crab Chasmagnathus model of associative contextual memory, NF-kB is activated specifically by retrieval and that this activation is required for memory consolidation and reconsolidation. Besides, the inhibition of NF-kB after memory reactivation impaired retention in inhibitory avoidance in mice. Now, our aim is to study the role of this transcription factor in reconsolidation and extinction in a paradigm of fear conditioning in mice. We found that hippocampal inhibition of NF-kB after reactivation impairs long-term memory, raising the question if this procedure impedes reconsolidation or facilitates extinction. We also found that the time course of NF-kB activation in hippocampal formation differs from what we have observed in extinction, thus supporting the hypothesis that both processes are sustained by different mechanisms.