Analysis of the GABAergic synaptic Inputs into mice Lateral Habenula

ALEJO MOSQUEIRA; OSVALDO D. UCHITEL; JOAQUIN PIRIZ

Huerta Grande

Congreso; Reunión Anual de la Sociedad Argentina de Neurociencias; 2013

Sociedad Argentina de Neurociencias

Lateral Habenula (LHb) is a small epithalamic structure that exerts a powerfulcontrol over dopaminergic brain stem centers and conveys negative motivationalsignals. Physiological information about synaptic transmission in the LHb is scarce;particularly there is no information about physiology of inhibitory afferences overLHb. In this work we have begun to characterize them. We found inhibitorysynapses over LHb to be clustered in two subpopulations one of big quantal sizeand another one of lower quantal size. High quantal size inhibitory synapses werepresent in half of the LHb recorded neurons, these neurons were alsocharacterized by a higher frequency of spontaneous inhibitory synaptic currents.Functional consequences of activation of this high quantal inhibitory input arediscussed.