IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
Autor/es:
MARTIN CARBÓ TANO; VICTOR A. MOLINA; MARÍA EUGENIA PEDREIRA
Lugar:
Huerta Grande, Córdoba
Reunión:
Congreso; XXVIII Congreso Anual de la SAN; 2013
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias
Resumen:
Extinction memory usually occurs after repeated or prolonged presentation of a conditioned stimulus (CS) that was previously associated with an unconditioned stimulus (US). It is widely accepted that fear extinction involves a new association between the CS and the absence of the US rather than the erasure of the CS?US association. We have demonstrated that an agonist of mammalian GABAA receptors impaired memory consolidation and reconsolidation, whereas an antagonist improved both processes. Considering that its assumed that extinction is a process based on inhibitory association, it seems possible to speculate thatinhibitory mechanisms may be required in order to acquire a memory that is inhibitory in nature. Using a combination of behavioral protocols andpharmacological treatments, we investigated the role of the GABAergic system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the GABAergic system facilitates and its inactivation impairs the extinction memory acquisition, and that diminishing the GABAergic tone before extinction test block its expression These results allow us to conclude that an active GABAergic system is necessary for the acquisition and expression of the extinction memory. This detailed description may contribute to understand the role of the GABAergic system in diverse aspects of the extinction memory.