Memory rectivation beyond expression: Increments of HSP70 triggered by memory reactivation in the protocerebrum of Chasmagnathus

203. NIEVA GV; BARREIRO KA; SUÁREZ LS; CLEMENTE J; PORTIANSKY EL; DELORENZI A.

HG

Congreso; XXVIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2013

SAN 2013

The reconsolidation hypothesis has challenged the traditional view of consolidation, including the notion that new memories are fixed and established. Previous studies of our group support the idea that mechanisms mediating memory reactivation and those dealing with behavioral expression of memory are dissociated. It was also shown that neural changes in the Lateral Protocerebrum (LP) of Chasmagnathus induced by different training protocols correlate with memory persistence, as evaluated by the capacity of memory to be reactivated and become labile, but not with the long-term expression of the reactivated memory. The central hypothesis of this Master´s Thesis project states that memory reactivation induces neuronal activity patterns in LP regardless memory expression. Its goal is to determine that memory built up after a weak training protocol can be reactivated even when long-term memory (LTM) induced by this training remains unexpressed. Using HSP70 as a neuronal activity marker of the LP we are evaluating whether unexpressed memories are reactivated, matter that will add evidence to the view that reactivation occurs independently of memory expression. Preliminary results show that memory reactivation of a consolidated but unexpressed memory induces an increase in HSP70 immunoreactivity in small neuropils of the LP.