IFIBYNE 05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Constraints on a module's effective sensitivity by the input and readout dynamic range
Autor/es:
EDGAR ALTSZYLER; ALEJANDRA C VENTURA; ALEJANDRO COLMAN-LERNER; ARIEL CHERNOMORETZ
Lugar:
Rosario
Reunión:
Conferencia; 4to. Congreso Argentina de Bioinformática y Biología Computacional (4CAB2C) y 4ta. Conferencia Internacional de la Sociedad Iberoamericana de Bioinformática (SolBio); 2013
Institución organizadora:
Asociación Argentina de Bioinformática y Biología Computacional
Resumen:
Many features of biochemical modules should be analyzed in a proper context to gain insight into how such a component behaves under physiological conditions. Using a very simple setup we explore how the dynamic range spanned by upstream and downstream components, and the nonlinearities of a general sigmoidal-shaped module?s response function could be tuned to produce effective sensitivities much less or even larger than the sensitivity associated to the original module when considered in isolation.
