IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Constrains on a module´s effective sensitivity by the input and readout dynamic range
Autor/es:
EDGAR ALTSZYLER; ALEJANDRA C VENTURA; ALEJANDRO COLMAN-LERNER; ARIEL CHERNOMORETZ
Lugar:
Buenos Aires
Reunión:
Workshop; XV Giambiagi Winter School, "Information processing in biological sytems, from cells to equations and back".; 2013
Institución organizadora:
Departamento de Física, FCEyN, UBA
Resumen:
Much work has been done on the study of the biochemical mechanisms that
result in ultrasensitive behavior of simple biochemical modules. However, in a
living cell, such modules are embedded in a bigger network that constrains the
range of inputs that the module will receive as well as the range of the
module?s outputs that network will be able to detect. Here, we studied how the
effective ultrasensitivity of a modular system is affected by these
restrictions. We use a simple setup to explore to what extent the dynamic range
spanned by upstream and downstream components of an ultrasensitive module
impact on the effective sensitivity of the system. Interestingly, we found for
some ultrasensitive motifs that dynamic range limitations imposed by downstream
components can produce effective sensitivities much larger than that of the
original module when considered in isolation.