Modafinil and Methamphetamine differentially activate c-Fos and FosB in the mouse striatum

MARIANA RAINERI; BETINA GONZALEZ; BELÉN GOITIA; JEAN LUD CADET; EDGAR GARCIA-RILL; FRANCISCO J. URBANO; VERÓNICA BISAGNO

Huerta Grande

Congreso; XXVIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2013

Sociedad Argentina de Investigación en Neurociencias

Modafinil (MOD) is an antinarcoleptic drug used off-label to treat psychostimulant addiction. High doses of METH can induce neurtoxicity in different brain areas. In the present study we aimed to explore MOD and METH acute effects on c-Fos and Fos-B activation (immediate early genes used as an index of neuronal activation) in striatal tissue. Female C57/Bl-6 mice were treated with a METH binge protocol (4x5mg/kg, i.p., 2 h apart) co-administrated with MOD (2x90 mg/kg, i.p., 1 h bef. 1st & 3rd METH inj.). We also investigated the effects of both psychostimulants in locomotor activity, catecholamine striatal content (by HPLC). METH and MOD administration induced hyperlocomotion compared to salines (p