Dissociation between the mechanisms mediating memory reactivation and that underling the behavioral expression of a declaratives memory

ALEJANDRO OJEA, KARINA BARREIRO, ALEJANDRO DELORENZI; ALEJANDRO DELORENZI

HG

Congreso; SAN 20123; 2013

SAN 2013

The reconsolidation hypothesis has challenged the traditional view of consolidation, including the notion that consolidated memories are fixed and established. Our previous reconsolidation?s studies in crabs and humans support the idea that there is dissociation between the mechanisms mediating memory reactivation and that underling the behavioral expression of memory. Recently, the lab have been demonstrated that both a mild stressor, cold pressor stress (CPS), and glucose can enhance declarative memory (association between five cuesyllables and their respective response-syllables) during reconsolidation, showing that the period in which this declarative memory can be reactivated and become labile largely exceeds the period in which that memory is expressed, proving evidence that conscious access is not needed for reconsolidation. The central goal of this project is to show that memory reactivation can occur regardless memory expression is interfered at retrievals sessions. Here, we expected that CPS administration both interfere with memory expression and positive modulated the reactivated memory during reconsolidation. Although very poor memory performance (expression) is expected at reactivation sessions, CPS will be still able to enhance reconsolidation, improving the long-term expression of the reactivated memory. This improving effect in memory expression is expected to be specific on the reconsolidation process.