CONICET | Buscador de Institutos y Recursos Humanos

Cognition, Behavior, and MemoryPoster Number 72 / Session IForgotten declarative memories can be reactivatedVerónica Coccoz , Adolfo Villalón Sandoval , Jimmy Stehberg , AlejandroDelorenzi 1 Centro de investigaciones Biomédicas., Universidad Andrés Bello.2 Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología yBiología Molecular y Celular, FCEyN, Universidad de Buenos Aires, IFIBYNECONICET,Argentina.3 Laboratorio de Neurobiología, Departamento de Ciencias Biológicas.Universidad Andrés Bello, Chile.verococcoz@gmail.comThe reconsolidation hypothesis has challenged the traditional view of fixedmemories after consolidation. Recently, we demonstrated that a mild stressor,cold pressor stress (CPS), can enhance declarative memory (associationbetween five cue-syllables and their respective response-syllables) duringreconsolidation. Here, we utilize positive modulation of memory expression todetermine whether 7 or 20 days old long-term unexpressed memories can be reexpressed by two different memory modulators: a mild stressor or glucose,during reconsolidation. Very poor memory performance was found atreactivation (day 6 and 20 after training). CPS can enhance reconsolidation,improving the long-term expression of memory 6 but not 20 days after training.However, we found that memory performance is robust at both one and threeweeks after training when a recognition test, instead free recall test was apply.Interestingly, the administration of an oral source of glucose (juice), but not adiet juice, can enhance memory during reconsolidation even 20 days aftertraining. Consequently, the period in which this memory can be reactivated andbecome labile largely exceed the period in which the memory is expressed.Results are consistent with the concept that memory labilization and behavioralexpression of memory are a dissociable processes