Differential effects of cocaine and methylphenidate on GABA release from thalamic reticular nucleus [537.11/C58]

GOITIA B; RAINERI M; GONZALEZ LE; ROZAS JL; GARCIA-RILL E; BISAGNO V; URBANO FJ

New Orleans, LA, USA

Congreso; 2012 Society for Neuroscience Meeting.; 2012

Society for Neuroscience

Cocaine (Coc) binge administration (3x15 mg/kg, 1h apart) to periadolescent mice (male C57BL/6, postnatal 18-23 days old) is known to alter spontaneous GABAergic transmission from the thalamic reticular nucleus (TRN) to the ventrobasal nucleus (VB). Still, the possible effects of methylphenidate (MPH), a psychostimulant used to treat attention deficit/hyperactivity disorder, binge administration (3x15 mg/kg, 1h apart) on GABAergic transmission from TRN remains unknown. We recorded GABAergic spontaneous minis currents from VB neurons from Coc or MPH binge treated mice. Coc but not MPH induced higher minis frequencies than saline (ANOVA plus Bonferroni post hoc test; p