Modafinil treatment counteracts methamphetamine-induced glial activation in mice striatal tissue. [459.05/T18]

RAINERI M; GONZALEZ B; GOITIA B; PESKIN V; GARCIA-RILL E; URBANO FJ; BISAGNO V

New Orleans, LA, USA

Congreso; 2012 Society for Neuroscience Meeting; 2012

Society for Neuroscience

Modafinil (MOD) is a stimulant drug used as a cognitive enhancer and it is also prescribed to treat psychostimulant addiction. Methamphetamine (METH) intake produces deleterious effects in brain areas including striatal toxicity and activation of glial cells. In order to determine if pre-treatment with MOD could counteract METH-induced glial activation in striatal tissue, female C57BL/6 mice were treated with a METH "binge" protocol (4x5mg/kg, i.p., 2h apart) co-administrated with MOD (2x90mg/kg, i.p., 1h before 1st and 4th METH injections). After 48hs, METH treated group exhibited striatal reactive microgliosis (measured by ILB4 immunostaining) and astrogliosis (measured by GFAP immunostaining). Tyrosine hydroxylase (TH) and dopamine transporter (DAT) immunostaining were not different than vehicle treated animals levels. METH+MOD treated animals showed glial activation values and TH and DAT levels that were similar to those found in vehicle groups (p