IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Vesicular trafficking of NMDA like receptors in Neohelice granulata (Chasmagnathus granulatus)
Autor/es:
HEPP, Y; FREUDENTHAL, R; PEDREIRA, ME
Lugar:
Huerta Grande, Córdoba
Reunión:
Congreso; XXVI Congreso Anual de la Sociedad Argentina de Investigación en Neurociencia; 2011
Institución organizadora:
Sociedad Argentina de Neurociencias
Resumen:
The NMDA glutamate receptors (NMDARs) mediate the majority of excitatory neurotransmission in the nervous system. Molecular and electrophysiological properties suggest that they may be the Hebbian´ coincidence detectors and has been implicated in synaptic plasticity, learning and memory. In the crab Neohelice granulata was demonstrated that the systemic administration of NMDAR antagonists (MK-801, APV) affects the memory consolidation, reconsolidation and extinction memory of the Context-Signal Memory. These results indicate that NMDA like receptors have been involved in long-term memory in this invertebrate model. Here we characterized the NMDA like receptors by Western blot assays and immunohistochemistry techniques. The next step was to evaluate the NR1 like receptor subunit expression as consequence of learning. Additionally, differential surface expression of NR1 like subunit was studied by semi-quantification of the intracellular and extracellular vesicular pool.