Intrinsic negative feedback in signaling cascades

JACQUES-A. SEPULCHRE; ALEJANDRA C VENTURA

Autrans

Conferencia; Réseaux de régulation multi-échelle et Transduction de signaux biologiques; 2011

French-speaking Society for Theoretical Biology

Previous studies have demonstrated that double phosphorylation of a protein can lead to bistability if some conditions are fulfilled. It was also shown that the signaling behavior of a covalent modification cycle can be quantitatively and, more importantly, qualitatively modified when this cycle is coupled to a signaling pathway as opposed to being isolated. This property was named retroactivity. These two results are studied together in this paper showing the existence of interesting phenomena -oscillations and bistability- in signaling cascades possessing at least one stage with a double-phosphorylation cycle.