IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
CALCINEURIN AND NUCLEAR FACTOR OF ACTIVATED T-CELLS (NFAT) INVOLVEMENT IN FEAR MEMORY CONSOLIDATION AND EXTINCTION
Autor/es:
DE LA FUENTE V; FEDERMAN N; ROMANO A
Lugar:
Huerta Grande. Provincia de Córdoba
Reunión:
Congreso; Second Joint Meeting of the Argentine Society for Neuroscience; 2010
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias (SAN)
Resumen:
In fear conditioning, aversive stimuli are readily associated with contextual features. A brief re-exposure to the training context causes fear memory reconsolidation, whereas a prolonged re-exposure induces memory extinction. The regulation of hippocampal gene expression plays a key role in contextual memory consolidation and reconsolidation. However, the mechanisms that determine whether memory will reconsolidate or extinguish are not known. We had already seen that NF-κB is required for fear memory reconsolidation. In the present work, we show that Calcineurin phosphatase (CaN) inhibits NF-κB, translocates to the nucleus and induces NFAT nuclear translocation, in the transition between reconsolidation and extinction. Accordingly, the hippocampal inhibition of both CaN and NFAT independently impairs memory extinction but not reconsolidation. We propose that CaN and NFAT are involved in the weakening of the original memory in extinction. We were also interested in study if inhibition of either of these two proteins has a facilitating role in consolidation of memory. Preliminary results show that inhibition of CaN immediately post training facilitates the consolidation of fear memory, whereas inhibition of NFAT shows no effect.