IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
capítulos de libros
Título:
What should be modeled in cancer: milestones for physical models
Autor/es:
SOFIA D MERAJVER; DEVIN T ROSENTHAL; ALEJANDRA C VENTURA
Libro:
Biophysical Modeling of Cancer
Editorial:
Springer
Referencias:
Año: 2011; p. 1 - 300
Resumen:
The field of mathematical oncology is exploding, with increasing efforts directed at laying down the foundation for the phenomena of cancer development, growth, metastases, and response to therapies. This work involves working at multiple spatio-temporal scales. The relative paucity of dynamical data renders many parametrical models challenging and limits their robustness. Concepts from engineering and nonlinear optical systems can be applied to cell signaling in the cancer cell yielding useful models. In this work, we explore the concepts of modularity, retroactivity, and pathway integration and delineate some of the outstanding questions that we believe should be prioritized for modeling in cancer.