CONICET | Buscador de Institutos y Recursos Humanos

The establishment of a successful pregnancy relies on a complex fetal-mother communication that starts with the embryo adhering and invading the endometrium. This invasion requires remodeling of extracellular matrix, performed by metalloproteinases. Cytokines, such as γ-interferon, play a role in implantation and could have profound effects on the success of pregnancy. Here we demonstrate that γ-IFN inhibits gelatinase activity from MMP-2 and -9 in a dose-dependent manner, reducing the secretion of leptin (not due to a general inhibition on protein synthesis) and impairs cell migration on Matrigel, using JEG-3/BeWo cell lines as cytotrophoblastic models. This correlates with previous reports from our laboratory indicating that γ-IFN is deleterious for mouse embryo outgrowth.