IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
The Immediately Releasable Pool: Highly Coupled Secretion in Neuroendocrine Cells
Autor/es:
YANINA ÁLVAREZ; FERNANDO D. MARENGO
Revista:
JOURNAL OF NEUROCHEMISTRY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2011 vol. 116 p. 155 - 163
ISSN:
0022-3042
Resumen:
In neuroendocrine cells, such as adrenal chromaffin cells, the
exocytosis of hormone-filled vesicles is triggered by a localized
Ca2+ increase that develops after the activation of voltage-
dependent Ca2+ channels. To reach the fusion competent
state, vesicles have to go through a series of maturation steps
that involve the detachment from cytoskeletal proteins, docking
and priming. However, the fusion readiness of vesicles will
also depend on their proximity to the calcium source. The
immediately releasable pool is a small group of ready-to-fuse
vesicles, whose fusion is tightly coupled to Ca2+ entry through
channels. Recent work indicates that such coupling is not
produced by a random distribution between vesicles and
channels, but would be the result of a specific interaction of
immediately releasable vesicles with particular Ca2+ channel
subtypes. The immediately releasable pool is able to sustain,
with high efficiency, the secretion triggered by the small and
localized Ca2+ gradients produced by brief depolarizations at
low frequencies, like action potentials at basal conditions in
adrenal chromaffin cells.2+ increase that develops after the activation of voltage-
dependent Ca2+ channels. To reach the fusion competent
state, vesicles have to go through a series of maturation steps
that involve the detachment from cytoskeletal proteins, docking
and priming. However, the fusion readiness of vesicles will
also depend on their proximity to the calcium source. The
immediately releasable pool is a small group of ready-to-fuse
vesicles, whose fusion is tightly coupled to Ca2+ entry through
channels. Recent work indicates that such coupling is not
produced by a random distribution between vesicles and
channels, but would be the result of a specific interaction of
immediately releasable vesicles with particular Ca2+ channel
subtypes. The immediately releasable pool is able to sustain,
with high efficiency, the secretion triggered by the small and
localized Ca2+ gradients produced by brief depolarizations at
low frequencies, like action potentials at basal conditions in
adrenal chromaffin cells.2+ channels. To reach the fusion competent
state, vesicles have to go through a series of maturation steps
that involve the detachment from cytoskeletal proteins, docking
and priming. However, the fusion readiness of vesicles will
also depend on their proximity to the calcium source. The
immediately releasable pool is a small group of ready-to-fuse
vesicles, whose fusion is tightly coupled to Ca2+ entry through
channels. Recent work indicates that such coupling is not
produced by a random distribution between vesicles and
channels, but would be the result of a specific interaction of
immediately releasable vesicles with particular Ca2+ channel
subtypes. The immediately releasable pool is able to sustain,
with high efficiency, the secretion triggered by the small and
localized Ca2+ gradients produced by brief depolarizations at
low frequencies, like action potentials at basal conditions in
adrenal chromaffin cells.2+ entry through
channels. Recent work indicates that such coupling is not
produced by a random distribution between vesicles and
channels, but would be the result of a specific interaction of
immediately releasable vesicles with particular Ca2+ channel
subtypes. The immediately releasable pool is able to sustain,
with high efficiency, the secretion triggered by the small and
localized Ca2+ gradients produced by brief depolarizations at
low frequencies, like action potentials at basal conditions in
adrenal chromaffin cells.2+ channel
subtypes. The immediately releasable pool is able to sustain,
with high efficiency, the secretion triggered by the small and
localized Ca2+ gradients produced by brief depolarizations at
low frequencies, like action potentials at basal conditions in
adrenal chromaffin cells.2+ gradients produced by brief depolarizations at
low frequencies, like action potentials at basal conditions in
adrenal chromaffin cells.