IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
Rapid Endocytosis and Vesicle Recycling in Neuroendocrine Cells
Autor/es:
ANA MARÍA CÁRDENAS; FERNANDO D. MARENGO
Revista:
CELLULAR AND MOLECULAR NEUROBIOLOGY.
Editorial:
SPRINGER/PLENUM PUBLISHERS
Referencias:
Año: 2010 vol. 30 p. 1365 - 1370
ISSN:
0272-4340
Resumen:
Endocytosis is a crucial process for neuroendocrine
cells that ensures membrane homeostasis, vesicle
recycling, and hormone release reliability. Different
endocytic mechanisms have been described in chromaffin
cells, such as clathrin-dependent slow endocytosis and
clathrin-independent rapid endocytosis. Rapid endocytosis,
classically measured in terms of a fast decrease in membrane
capacitance, exhibits two different forms, rapid
compensatory endocytosis and excess retrieval. While
excess retrieval seems to be associated with formation of
long-lasting endosomes, rapid compensatory endocytosis is
well correlated with exocytotic activity, and it is regarded
as a mechanism associated to rapid vesicle recycling during
normal secretory activity. It has been suggested that rapid
compensatory endocytosis may be related to the prevalence
of a transient fusion mode of exo-endocytosis. In the latter
mode, the fusion pore, a nanometric-sized channel formed
at the onset of exocytosis, remains open for a few hundred
milliseconds and later abruptly closes, releasing a small
amount of transmitters. By this mechanism, endocrine cell
selectively releases low molecular weight transmitters, and
rapidly recycles the secretory vesicles. In this article, we
cells that ensures membrane homeostasis, vesicle
recycling, and hormone release reliability. Different
endocytic mechanisms have been described in chromaffin
cells, such as clathrin-dependent slow endocytosis and
clathrin-independent rapid endocytosis. Rapid endocytosis,
classically measured in terms of a fast decrease in membrane
capacitance, exhibits two different forms, rapid
compensatory endocytosis and excess retrieval. While
excess retrieval seems to be associated with formation of
long-lasting endosomes, rapid compensatory endocytosis is
well correlated with exocytotic activity, and it is regarded
as a mechanism associated to rapid vesicle recycling during
normal secretory activity. It has been suggested that rapid
compensatory endocytosis may be related to the prevalence
of a transient fusion mode of exo-endocytosis. In the latter
mode, the fusion pore, a nanometric-sized channel formed
at the onset of exocytosis, remains open for a few hundred
milliseconds and later abruptly closes, releasing a small
amount of transmitters. By this mechanism, endocrine cell
selectively releases low molecular weight transmitters, and
rapidly recycles the secretory vesicles. In this article, we
cells that ensures membrane homeostasis, vesicle
recycling, and hormone release reliability. Different
endocytic mechanisms have been described in chromaffin
cells, such as clathrin-dependent slow endocytosis and
clathrin-independent rapid endocytosis. Rapid endocytosis,
classically measured in terms of a fast decrease in membrane
capacitance, exhibits two different forms, rapid
compensatory endocytosis and excess retrieval. While
excess retrieval seems to be associated with formation of
long-lasting endosomes, rapid compensatory endocytosis is
well correlated with exocytotic activity, and it is regarded
as a mechanism associated to rapid vesicle recycling during
normal secretory activity. It has been suggested that rapid
compensatory endocytosis may be related to the prevalence
of a transient fusion mode of exo-endocytosis. In the latter
mode, the fusion pore, a nanometric-sized channel formed
at the onset of exocytosis, remains open for a few hundred
milliseconds and later abruptly closes, releasing a small
amount of transmitters. By this mechanism, endocrine cell
selectively releases low molecular weight transmitters, and
rapidly recycles the secretory vesicles. In this article, we
Endocytosis is a crucial process for neuroendocrine
cells that ensures membrane homeostasis, vesicle
recycling, and hormone release reliability. Different
endocytic mechanisms have been described in chromaffin
cells, such as clathrin-dependent slow endocytosis and
clathrin-independent rapid endocytosis. Rapid endocytosis,
classically measured in terms of a fast decrease in membrane
capacitance, exhibits two different forms, rapid
compensatory endocytosis and excess retrieval. While
excess retrieval seems to be associated with formation of
long-lasting endosomes, rapid compensatory endocytosis is
well correlated with exocytotic activity, and it is regarded
as a mechanism associated to rapid vesicle recycling during
normal secretory activity. It has been suggested that rapid
compensatory endocytosis may be related to the prevalence
of a transient fusion mode of exo-endocytosis. In the latter
mode, the fusion pore, a nanometric-sized channel formed
at the onset of exocytosis, remains open for a few hundred
milliseconds and later abruptly closes, releasing a small
amount of transmitters. By this mechanism, endocrine cell
selectively releases low molecular weight transmitters, and
rapidly recycles the secretory vesicles. In this article, we